See a Doctor
who believes you

The Link Between Neurodiversity, Hypermobility, and EDS

Updated:
September 2024
by
David Harris

The Significance of Neurodiversity in Healthcare

Neurodiversity, a concept that highlights the diverse spectrum of human brain functions, is gaining increasing recognition in the medical community. This approach encompasses conditions such as autism, ADHD, dyslexia, and OCD, advocating for a deeper understanding and acceptance of these neurological differences. The neurodiversity movement is not just about awareness; it's about appreciating these differences as natural variations of the human experience, requiring accommodations and inclusive practices.

Joint Hypermobility and Its Neurological Implications

Joint hypermobility, particularly prevalent in conditions like Ehlers-Danlos Syndrome (hEDS), is more than just a physical attribute; it has notable neurological implications. Recent studies have discovered that individuals with joint hypermobility, including those with hEDS, often exhibit unique brain functions, especially in regions like the amygdala that are involved in processing emotions and fear. This discovery suggests a complex interplay between physical and neurological traits in these individuals.

The Overlap of Ehlers-Danlos Syndrome with ADHD and Autism

A growing body of evidence indicates a significant overlap between Ehlers-Danlos Syndrome and neurodevelopmental disorders such as ADHD and autism spectrum disorder (ASD). A Swedish national registry study and other research have shown a positive association between EDS and these neurodevelopmental disorders, suggesting a shared underlying pathophysiology​​. Notably, ADHD is more common in individuals with hEDS compared to those with HSD, with prevalence rates as high as 46% in certain age groups​​.

The Neurodevelopmental Impact of Hypermobility Spectrum Disorders

Hypermobility Spectrum Disorders (HSD), which include hEDS, are associated with a range of neurodevelopmental impacts. Children with HSD or hEDS often exhibit behavioral problems, hyperactivity, and autistic traits. In fact, children with these conditions may need routine screening for neuropsychiatric symptoms, given the strong association between HSD/hEDS and ADHD/ASD​​​​.

Managing Comorbid Conditions in Ehlers-Danlos Syndrome

For individuals with EDS, managing the physical symptoms is just one aspect of their healthcare. Given the high prevalence of psychiatric conditions such as anxiety and depression, a comprehensive approach that addresses these comorbidities is essential. Effective management of these conditions can significantly improve the quality of life for those with EDS.

The Role of Joint Hypermobility in Neurodivergence

In neurodivergent individuals, joint hypermobility appears to play a key role in the manifestation of symptoms like dysautonomia and pain. Some might say this link is driven by the connection between the gut and the brain (aka the gut-brain axis), but this link is still being proven out in the research. No matter the pathway, this relationship underscores the need to consider physical symptoms within the context of neurodivergence, offering insights into potential treatment and support strategies.

Conclusion: A Call for Holistic Approaches in Neurodivergent Care

The neurodiversity paradigm advocates for a shift in perspective, where brain differences are seen as part of the natural human spectrum, not as deficits. Neurodivergent individuals, particularly those with physical conditions like EDS, face unique challenges that are often exacerbated in environments lacking understanding and support. Recognizing and addressing the interconnectedness of neurological and physical conditions is crucial for providing comprehensive, empathetic care.

References:

  1. Bulbena, A., Gago, J., Pailhez, G., Sperry, L., Fullana, M. A., & Vilarroya, O. (2009). Joint hypermobility syndrome is a risk factor trait for anxiety disorders: A 15-year follow-up cohort study. General Hospital Psychiatry, 31(4), 317-323. https://pubmed.ncbi.nlm.nih.gov/21762833/
  2. Eccles, J. A., Beacher, F. D., Gray, M. A., et al. (2012). Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms. The British Journal of Psychiatry, 200(6), 508-509. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365276/
  3. Pacey, V., Tofts, L., Adams, R. D., Munns, C. F., & Nicholson, L. L. (2015). Quality of Life prediction in children with joint hypermobility syndrome. Journal of Paediatrics and Child Health, 51(7), 689-695. https://pubmed.ncbi.nlm.nih.gov/25622801/
  4. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). https://www.psychiatry.org/psychiatrists/practice/dsm
  5. Kindgren, E., Perez, A., Knez, R, (2021). Disorder in Children with HypermobilitySpectrum Disorders or HypermobileEhlers-Danlos Syndrome: A Retrospective Study, Neuropsychiatric Disease and Treatment, https://pubmed.ncbi.nlm.nih.gov/33603376/
  6. Csecs, Jenny L. L., et al. “Joint Hypermobility Links Neurodivergence to Dysautonomia and Pain.” Frontiers, Frontiers, 20 Dec. 2021, www.frontiersin.org/articles/10.3389/fpsyt.2021.786916/full.
  7. B;, Kennedy M;Loomba K;Ghani H;Riley. “The Psychological Burden Associated with Ehlers-Danlos Syndromes: A Systematic Review.” Journal of Osteopathic Medicine, U.S. National Library of Medicine, pubmed.ncbi.nlm.nih.gov/35420002/. Accessed 2 Dec. 2023.
  8. Casanova, Emily L, et al. “The Relationship between Autism and Ehlers-Danlos Syndromes/Hypermobility Spectrum Disorders.” Journal of Personalized Medicine, U.S. National Library of Medicine, 1 Dec. 2020, www.ncbi.nlm.nih.gov/pmc/articles/PMC7711487/.

See a Doctor
who believes you