The Best MCAS Specialists in the USA by state

Mast Cell Activation Syndrome (MCAS) is a complex condition that requires specialized care from knowledgeable physicians familiar with mast cell disorders, connective tissue diseases, and related conditions such as Ehlers-Danlos Syndrome (EDS) and dysautonomia. Finding an experienced MCAS specialist can be challenging; therefore, we've compiled a state-by-state guide to some of the best clinicians in the U.S. who focus on MCAS treatment. This list includes leading experts in MCAS diagnosis and treatment. Many of these MCAS specialists work at The EDS Clinic, but those who do not are indicated by an asterisk (*).

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Meet the Experts: Leading MCAS Specialists in the U.S.

Dr. Jim Harris, MD – Medical Director, The EDS Clinic

Dr. Jim Harris is the Medical Director of The EDS Clinic, specializing in MCAS, Ehlers-Danlos Syndrome (EDS), and Postural Orthostatic Tachycardia Syndrome (POTS). He is board-certified in Allergy & Immunology and has conducted nearly 300 research studies, including trials involving Xolair, an important MCAS therapeutic. Dr. Harris is widely recognized for his work in diagnosing and managing complex multisystem disorders.​

Dr. Sarah Bohrer, MD – MCAS Specialist, The EDS Clinic

Dr. Sarah Bohrer is a compassionate and experienced physician with over 20 years of expertise. Her personal journey with her family's health challenges led her to specialize in EDS, MCAS, and POTS. She has worked in diverse medical settings, including private practice, federally qualified health centers, urgent care, inpatient pediatrics, and residential mental health care. Dr. Bohrer earned her medical degree from SUNY Buffalo College of Medicine and completed her pediatric residency at North Shore University Hospital in Manhasset, NY. She is board-certified by the American Board of Pediatrics and holds medical licenses in Connecticut, New York, and North Carolina.

Dr. Andrea Joplin, MD – EDS and MCAS Specialist, The EDS Clinic

Dr. Andrea Joplin brings 25 years of clinical experience and a wealth of expertise to The EDS Clinic. Her personal experience with hypermobile Ehlers-Danlos syndrome (hEDS) provides her with a unique perspective and deep-seated dedication to serving people affected by EDS. Dr. Joplin earned her medical degree from the University of Minnesota, where she also completed a residency in ophthalmology. She serves on the Medical Board of the Connective Tissue Coalition, an organization dedicated to promoting connective tissue disease research, advocacy, and education among healthcare providers.

Dr. Sujana Reddy, DO – Chronic Illness Specialist, The EDS Clinic

Dr. Sujana Reddy is a compassionate physician whose personal health journey profoundly influences her medical practice. Diagnosed with Ehlers-Danlos Syndrome (EDS) at 28, she has firsthand experience with chronic illness complexities. Her battle with long-term effects of COVID-19 further deepened her insight into such conditions. Dr. Reddy earned her Doctor of Osteopathic Medicine degree from the Alabama College of Osteopathic Medicine in 2021 and completed her Internal Medicine training at East Alabama Health in 2024. She actively serves on the board of Awareness For Potsies, advocating for individuals with Postural Orthostatic Tachycardia Syndrome (POTS). Her experiences have made her a dedicated advocate for patient empowerment and understanding.

Carolyn Martinez, MSN, RN, FNP – Nurse Practitioner, The EDS Clinic

Carolyn Martinez, FNP brings over 15 years of experience as a family nurse practitioner, with expertise in urgent care, primary care, and cardiology. Fluent in English and Spanish, she has dedicated her career to serving underserved communities across California and New Mexico. Over the past six years, Carolyn has focused on supporting the EDS community and related conditions such as POTS, Mast Cell Activation Syndrome (MCAS), gastrointestinal dysmotility disorders, and chronic pain. She completed EDS ECHO training through The Ehlers-Danlos Society and has been instrumental in diagnosing and treating numerous individuals with EDS. Carolyn earned her Master of Science in Nursing from the University of California, San Francisco, and a Bachelor of Arts in Public Health from Johns Hopkins University, where she was inducted into Phi Beta Kappa. Known for her empathetic approach, she ensures patients feel seen, heard, and supported as they navigate complex medical conditions.

Dr. Larry Afrin, MD – Hematology/Oncology & Mast Cell Disease Specialist, AIM Center for Personalized Medicine*

Dr. Lawrence Afrin* is a leading hematologist-oncologist specializing in mast cell disorders, including MCAS. He earned his medical degree from the Medical University of South Carolina (MUSC) and has held faculty positions at MUSC and the University of Minnesota. Dr. Afrin has published extensively in the peer-reviewed medical literature and is the author of the first book about MCAS, consistently acclaimed by physicians and patients since its publication in 2016. Dr. Afrin works at the AIM Center for Personalized Medicine (*not affiliated with The EDS Clinic).

Dr. Tania Dempsey, MD – Founder, AIM Center for Personalized Medicine*

Dr. Tania Dempsey* specializes in autoimmune diseases, MCAS, and chronic illnesses. She received her MD from The Johns Hopkins University School of Medicine and her BS degree from Cornell University. Dr. Dempsey founded the AIM Center for Personalized Medicine, where she focuses on investigating the root causes of complex conditions, integrating both conventional and functional medicine approaches. (*not affiliated with The EDS Clinic). Dr. Dempsey is the founder of the AIM Center for Personalized Medicine (*not affiliated with The EDS Clinic).

Dr. David Saperstein, MD – Neurology and MCAS Specialist, Center for Complex Neurology, EDS & POTS

Dr. David Saperstein is a board-certified neurologist and Director of the Center for Complex Neurology, EDS & POTS in Phoenix, Arizona. He specializes in dysautonomia, small fiber neuropathy, and mast cell disorders, including MCAS, with a focus on neurological complications of Ehlers-Danlos Syndrome (EDS) and Postural Orthostatic Tachycardia Syndrome (POTS). Board-certified in Neurology, Neuromuscular Medicine, Clinical Neurophysiology, and Clinical Neuromuscular Pathology, Dr. Saperstein also serves as a Clinical Associate Professor of Neurology at the University of Arizona College of Medicine. He was awarded the 2021 Community Choice Award for Healthcare Professionals by The Ehlers-Danlos Society for his commitment to patient-centered care. (Not affiliated with The EDS Clinic)

Dr. Jenny Zhang, MD – EDS and MCAS Specialist, The EDS Clinic

Dr. Jenny Zhang offers more than a decade of extensive clinical experience, encompassing specialized training in both general surgery and anesthesiology. Her personal journey with hypermobile Ehlers-Danlos syndrome (hEDS) has profoundly shaped her career and aspirations, fueling her dedication to delivering exceptional care and advocacy for the EDS and hypermobile community. Dr. Zhang received her medical degree from the Louisiana State University Health Sciences Center in New Orleans and currently resides in Seattle. She is also a classically-trained chef with a dedicated interest in the concept of "food as medicine," utilizing culinary medicine to enhance the management of chronic illnesses and overall quality of life.

Dr. Brittany Goss, DO – Board Certified Rheumatologist, The EDS Clinic

Dr. Brittany Goss, DO, FACOI, FACR, is a highly experienced rheumatologist and internal medicine physician with over 16 years of expertise in diagnosing and managing complex connective tissue disorders and other rheumatological conditions. She is passionate about improving the care and quality of life for patients with hypermobility disorders, Ehlers-Danlos syndrome (EDS), and their associated comorbidities, including Mast Cell Activation Syndrome (MCAS), Postural Orthostatic Tachycardia Syndrome (POTS), and other forms of dysautonomia. Dr. Goss earned her Doctor of Osteopathy degree from the Lake Erie College of Osteopathic Medicine and completed her internal medicine residency and rheumatology fellowship at Largo Medical Center, where she served as Chief Rheumatology Fellow. She is board-certified in both rheumatology and internal medicine and holds the Fellow of the American College of Osteopathic Internists (FACOI) and Fellow of the American College of Rheumatology (FACR) designations.

Dr. Pradeep Chopra, MD – Director, Center for Complex Conditions*

Dr. Pradeep Chopra* is a Harvard-trained pain medicine specialist with over 25 years of experience treating complex chronic pain and multisystem disorders. He is board-certified in both Pain Medicine and Anesthesiology and serves as an Assistant Clinical Professor at Brown University’s Warren Alpert Medical School. Dr. Chopra is the Director of the Center for Complex Conditions, where he specializes in Ehlers-Danlos Syndrome (EDS), Complex Regional Pain Syndrome (CRPS), and Mast Cell Activation Syndrome.
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The Best MCAS Specialists by State

California

• Dr. Brittany Goss, DO (The EDS Clinic)
• Carolyn Martinez, MSN, RN, FNP (The EDS Clinic)

Texas

• Dr. Jim Harris, MD (The EDS Clinic)

Illinois

• Dr. Jim Harris, MD (The EDS Clinic)

Ohio

• Dr. Jim Harris, MD (The EDS Clinic)
• Dr. Sarah Bohrer, MD (The EDS Clinic)

North Carolina

• Dr. Sarah Bohrer, MD (The EDS Clinic)

Michigan

• Dr. Sarah Bohrer, MD (The EDS Clinic)‍
• Dr. Jim Harris, MD (The EDS Clinic)

New Jersey

• Dr. Jim Harris, MD (The EDS Clinic)

Washington

• Dr. Jenny Zhang, MD (The EDS Clinic)‍
• Dr. Jim Harris, MD (The EDS Clinic)

New York

• Dr. Larry Afrin, MD (AIM Center for Personalized Medicine*)
• Dr. Tania Dempsey, MD (AIM Center for Personalized Medicine*)
• Dr. Anne Maitland, MD (Comprehensive Allergy and Asthma Care*)

Arizona

• Dr. David Saperstein, MD (Center for Complex Neurology, EDS & POTS*)

Indiana

• Dr. Jim Harris, MD (The EDS Clinic)

Wisconsin

• Dr. Jim Harris, MD (The EDS Clinic)

Colorado

• Dr. Jim Harris, MD (The EDS Clinic)
• Dianne Villanni, NP (The EDS Clinic)

Minnesota

• Dr. Jim Harris, MD (The EDS Clinic)
• Dr. Andrea Joplin, MD (The EDS Clinic)

Alabama

• Dr. Jim Harris, MD (The EDS Clinic)
• Dr. Sujana Reddy, DO (The EDS Clinic)

Rhode Island

• Dr. Pradeep Chopra, MD (Center for Complex Conditions*)

Providers and clinics noted with an asterisk are not affiliated with www.EDS.clinic

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