Hereditary Alpha Tryptasemia

Hereditary Alpha Tryptasemia (HaT) is characterized by high blood tryptase levels. It is a genetically linked condition that is caused by having additional copies of the TPSAB1 gene encoding the protein α-tryptase. HaT can produce a wide range of symptoms across multiple organ systems symptoms which can make it difficult to identify. Many of the symptoms are similar to Mast Cell Activation Syndrome.

POSSIBLE SYMPTOMS
Mental: Anxiety / ADHD / Brain fog (e.g. difficulty concentrating or recalling words) /Depression / Irritability / Mood swings / Panic attacks
Gastrointestinal: Abdominal Pain / Constipation / Cramping / Diarrhea /Nausea
Dermatological: Flushing / Hives / Itching / Dermatographia
Respiratory: Chronic congestion / Coughing / Nasal stuffines / Wheezing
Cardiovascular: Heart palpitations or racing heart beat / Dizziness / Low blood pressure or High blood pressure / Fainting / Near-fainting / Lightheadedness
Vision: Blurred vision / Dry irritated eyes / Red eyes
Auditory: Sound sensitivity / Tinnitus
Pain: Headaches / Migraines / Joint pain / Chest pain / Abdominal pain
Anaphylaxis: difficulty breathing / itchy hives / flushing  / weak and rapid pulse / nausea / vomiting / diarrhea / dizziness and/or fainting
Other: Weight gain / Slow wound healing / high sensitivity to smells

Meet some of our best HaT specialists

Dr. Jim Harris, MD
Medical Director
Ashley Stoecker, DO
Board Certified Family Medicine Physician
Andrea Joplin, MD
‍Board Certified Physician

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