Hereditary Alpha Tryptasemia (HaT)

Hereditary Alpha Tryptasemia (HaT) is characterized by high blood tryptase levels. It is a genetically linked condition that is caused by having additional copies of the TPSAB1 gene encoding the protein α-tryptase. HaT can produce a wide range of symptoms across multiple organ systems symptoms which can make it difficult to identify. Many of the symptoms are similar to Mast Cell Activation Syndrome.

‍

POSSIBLE SYMPTOMS

Mental: Anxiety / ADHD / Brain fog (e.g. difficulty concentrating or recalling words) /Depression / Irritability / Mood swings / Panic attacks

Gastrointestinal: Abdominal Pain / Constipation / Cramping / Diarrhea /Nausea

Dermatological: Flushing / Hives / Itching / Dermatographia

Respiratory: Chronic congestion / Coughing / Nasal stuffines / Wheezing

Cardiovascular: Heart palpitations or racing heart beat / Dizziness / Low blood pressure or High blood pressure / Fainting / Near-fainting / Lightheadedness

Vision: Blurred vision / Dry irritated eyes / Red eyes

Auditory: Sound sensitivity / Tinnitus

Pain: Headaches / Migraines / Joint pain / Chest pain / Abdominal pain

Anaphylaxis: difficulty breathing / itchy hives / flushing  / weak and rapid pulse / nausea / vomiting / diarrhea / dizziness and/or fainting

Other: Weight gain / Slow wound healing / high sensitivity to smells

‍